NURR1 activation in skeletal muscle controls systemic energy homeostasis
نویسندگان
چکیده
منابع مشابه
A MED13-dependent skeletal muscle gene program controls systemic glucose homeostasis and hepatic metabolism.
The Mediator complex governs gene expression by linking upstream signaling pathways with the basal transcriptional machinery. However, how individual Mediator subunits may function in different tissues remains to be investigated. Through skeletal muscle-specific deletion of the Mediator subunit MED13 in mice, we discovered a gene regulatory mechanism by which skeletal muscle modulates the respo...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2019
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.1902490116